Disrupted Circadian Rhythm (DCR)
Environmental (sleep disruption, artificial lighting, illness etc.) and genetic factors result in disruption of the circadian rhythm.
In ageing, neurodegenerative diseases and the metabolic syndrome (MS) a wide variety of circadian or sleep-wake cycle disruptions occur.
Disrupted circadian rhythms are frequently observed in patients with neurodegenerative disease, including Autism Spectrum Disorder (ASD), Alzheimer disease (AD), Parkinson disease (PD), Huntington disease (HD). The circadian influence on the dynamics and kinetics of medications for patients with cancer, asthma, hypertension, or diabetes is although significant in drug efficacy.
Genetic alterations in clock gene transcription can result in a modification or disruption of circadian oscillators. Therefore, modulating the transcriptional activity of clock proteins in patients with a dramatically changed oscillation or activity of those regulators could be efficacious in treating circadian rhythm-based diseases.
How is the circadian clock regulated?
Circadian clocks are regulated by core transcription-translation–regulatory feedback loops, a specific set of regulators called clock proteins. Most of behavioral and physiologic processes oscillate with a 24 h period, including activity, sleep, hormone secretion, body temperature, blood pressure, and eating patterns.
Overview of the human circadian rhythm
In humans, the circadian rhythm is maintained via the function of the body’s master clock in the suprachiasmatic nucleus (SCN), which synchronizes oscillations in peripheral organs. The photic or light time cue (termed Zeitgeber) is the most potent circadian cue, but non-photic cue such as time of feeding (eating or fasting), temperature changes and time of physical activity/exercise although influence the molecular rhythms and behavior.
Environmental (sleep disruption, artificial lighting, illness etc.) and genetic factors result in disruption of the circadian rhythm.
In ageing, neurodegenerative diseases and the metabolic syndrome (MS) a wide variety of circadian or sleep-wake cycle disruptions occur.
Disrupted circadian rhythms are frequently observed in patients with neurodegenerative disease, including Autism Spectrum Disorder (ASD), Alzheimer disease (AD), Parkinson disease (PD), Huntington disease (HD). The circadian influence on the dynamics and kinetics of medications for patients with cancer, asthma, hypertension, or diabetes is although significant in drug efficacy.
Genetic alterations in clock gene transcription can result in a modification or disruption of circadian oscillators. Therefore, modulating the transcriptional activity of clock proteins in patients with a dramatically changed oscillation or activity of those regulators could be efficacious in treating circadian rhythm-based diseases.
How is the circadian clock regulated?
Circadian clocks are regulated by core transcription-translation–regulatory feedback loops, a specific set of regulators called clock proteins. Most of behavioral and physiologic processes oscillate with a 24 h period, including activity, sleep, hormone secretion, body temperature, blood pressure, and eating patterns.
Overview of the human circadian rhythm
In humans, the circadian rhythm is maintained via the function of the body’s master clock in the suprachiasmatic nucleus (SCN), which synchronizes oscillations in peripheral organs. The photic or light time cue (termed Zeitgeber) is the most potent circadian cue, but non-photic cue such as time of feeding (eating or fasting), temperature changes and time of physical activity/exercise although influence the molecular rhythms and behavior.